Dementia can be caused by hypertension?


Dementia can be caused by hypertension?

Hypertension is a chronic condition that causes dynamic organ damage. It is shown that most by majority of cases of Alzheimer's disease and related dementia are not because of genetic predisposition but rather to chronic exposure to vascular risk factors.

The clinical approach to treatment of dementia patients for the most part begins simply after side effects are clearly evident. However, it has turning out to be progressively certain that when indications of brain damage are manifest, it might be past the point where it is possible to switch the neurodegenerative process. hypertension despite everything need methods for evaluating movement markers that could exposed pre-symptomatic alterations and identify patients in danger of developing dementia. The work was conducted on patients with no effects of structural damage and no diagnosis of dementia. All patients Stand clinical examination to determine their high blood pressure status and the related target organ risk. Additionally, patients were interested to an MRI scan to know microstructural damage. To improve insights in the neurocognitive profile of patients a specific group tests was conducted. Researchers target is major outcome of the study at finding any specific mark of brain changes in white matter microstructure of hypertensive patients, associated with an impairment of the related cognitive functions.

The result indicated that hypertensive patients prove important alterations in three specific white matter fiber-tracts. patients  of hypertensive also mainly worse in the cognitive domains ascribable to brain regions interlinked through those fiber-tracts, presenting decreased performances in executive functions, processing speed, memory and related learning tasks. Overall, white matter fiber-tracking on MRIs indicate an early sign of risk in hypertensive patients when otherwise undetectable by conventional neuroimaging. As these changes by absorbing before patients have symptoms, these patients could be targeted with medication earlier to prevent further deterioration in brain function. These findings are also rarely applicable to other forms of neurovascular illness, where early intervention could be of marked therapeutic benefit.

"The problem is that neurological alterations related to high blood pressure are usually diagnosed only when the cognitive deficit becomes proved, or when traditional magnetic resonance shows clear indication of brain damage. In both cases, it is often too delay to stop the pathological process. We have been able to observe that, in the hypertensive cases, there was identification of white matter fibers connecting brain areas typically include in attention, feelings and memory. It is an important issue to consider is that all the hypertensive patients studied did not show clinical mark of dementia and, in conventional neuroimaging, they showed no signs of cerebral damage. However, further studies will be important, but we thought that the use of tractography will lead to the early identification of people at risk of dementia, allowing timely therapeutic interventions."


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